Kink-Ease™ MSM Salve “gets the kinks out” of aching and tight muscles and joints caused by over-exertion, sports injury, arthritis and the stress of life, without the side effects of pain medications.

This “ultra-pure/ultra-potent” formula was exclusively developed by pain-medicine physician, David S. Klein, MD,  who uses these ingredients to ease the pain of his patients, including professional athletes. 

Kink-Ease™ contains as much as 10 times the active ingredient - MSM - compared with other popular brands.

Just rub Kink-Ease™ salve over the area of pain or discomfort. The active ingredient, MSM (methylsulfonylmethane) — a non-toxic natural compound — is carried through the skin to begin the soothing process.  For knee pain, try rubbing Kink-Ease on the back and side of the knee.

The salve may need to be applied three or four times a day. See your health care professional for more information.

Kink-Ease™ may also improve flexibility in tight muscles and is an excellent product for softening feet and rough heals.

www.kinkease.com

See the "facts" tab for more detailed medical information.

* Try Kink-Ease Risk Free.   If you are not 100% satisfied with this product, return within 30 days of purchase date for a refund, minus original shipping and handling costs. 

Methylsulfonylmethane (MSM) - One of nature's richest sources of sulfur, MSM offers one of the most significant portions of sulfur (34% by weight) of any other compound. As such, MSM is an ideal supplement for the American diet which has progressively declined in sulfur content. Kinkease is a pharmaceutical grade salve, available in an over the counter preparation.

Sulfur ranks as the third highest substance by weight in the body’s chemistry besides water and gases, playing a major role in maintaining the body’s overall balance of health. In mammals, the concentration of MSM in the body decreases with age, making it difficult for the body to generate new healthy cells, an integral part of sulfur’s role.

Results of several studies showed that supplementation with MSM significantly reduced joint degeneration and inflammation. Important for generation of connective tissues for everything from hair to cartilage, collagen to skin, sulfur is crucial for the production of amino acids which are the building blocks of protein. Sulfur is also important for the repair of tissues damaged by injury, free radical attack, aging, etc.

Methylsulfonyl Methane (MSM)

MSM is widely used as an anti-inflammatory medication (6) and as an adjunctive agent in the treatment of pain. MSM is widely found in nature, and is essentially non-allergenic. Cow's milk is the most abundant source of MSM, containing 3.3 parts per million (ppm).

MSM relieves pain through several mechanisms of action. Acting as an anti-inflammatory agent, reduction in tissue swelling, reduction in vasodilation, pain is reduced. MSM may reduce muscle spasm and MSM reduces the rate of pain impulse activity in the C-fiber component of the peripheral nervous system. There is evidence that MSM may have value as a cancer preventive agent. (3). Using multinuclear magnetic resonance spectroscopy it was observed that MSM crosses the blood-brain barrier (BBB) in significant concentration. The study also revealed that MSM is evenly distributed throughout the brain, including the brainstem, with equal concentrations in both gray and white matter. Other studies confirm MSM crosses the BBB. (4, 5)

MSM is very safe to administer, having a very low toxicity. (7, 8) Methylsulfonylmethane (MSM) is a popular dietary supplement used in a variety of conditions including pain, inflammation, allergies, arthritis, parasitic infections, and bladder conditions. It is thought to maintenance of normal keratin levels in hair, skin and nails. Toxicity studies have concluded that MSM is well tolerated in doses that exceed 2 g/kg. (1)

Compared to placebo, MSM produced significant decreases in pain and physical functional. MSM also produced improvement in performing activities of daily living when compared to placebo. (2)

1. Horváth K, Noker PE, et al: Toxicity of methylsulfonylmethane in rats. Food 2002 Oct; 40(10):1459-62.

2. Kim LS, Axelrod LJ, et al: Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis2006 Mar; 14(3):286-94.

3. Ebisuzaki K: Aspirin and methylsulfonylmethane (MSM): a search for common mechanisms, with implications for cancer prevention. Anticancer Res. 2003 Jan-Feb; 23(1A):453-8.

4. Cecil KM, Lin A, Ross BD, Egelhoff JC. Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation. J Comput Assist Tomogr 2002;26:818-820.

5. Rose SE, Chalk JB, Galloway GJ, Doddrell DM. Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy. Magn Reson Imaging 2000;18:95-98.

6. Beilke MA, Collins-Lech C, Sohnle PG. Effects of dimethyl sulfoxide on the oxidative function of human neutrophils. J Lab Clin Med 1987;110:91-96.
7. Morton JI, Siegel BV. Effects of oral dimethyl sulfoxide and dimethyl sulfone on murine autoimmune lymphoproliferative disease. Proc Soc Exp Biol Med 1986:183:227-230.
8. Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med 2002;8:167-173.